Scientists temporarily attached a pig’s kidney to a human body and watched it begin to work, a small step in the decades-long quest to one day use animal organs for lifesaving transplants.

Pigs have been the most recent research focus to address the organ shortage, but among the hurdles: A sugar in pig cells, foreign to the human body, causes immediate organ rejection. The kidney for this experiment came from a gene-edited animal, engineered to eliminate that sugar and avoid an immune system attack.

Surgeons attached the pig kidney to a pair of large blood vessels outside the body of a deceased recipient so they could observe it for two days. The kidney did what it was supposed to do — filter waste and produce urine — and didn’t trigger rejection.

“It had absolutely normal function,” said Dr. Robert Montgomery, who led the surgical team last month at NYU Langone Health in New York. “It didn’t have this immediate rejection that we have worried about.”

This research is “a significant step,” said Dr. Andrew Adams of the University of Minnesota Medical School, who was not part of the work. It will reassure patients, researchers and regulators “that we’re moving in the right direction.”

The dream of animal-to-human transplants, or xenotransplantation, dates to the 17th century with stumbling attempts to use animal blood for transfusions. By the 20th century, surgeons were attempting transplants of organs from baboons into humans, notably Baby Fae, a dying infant, who lived 21 days with a baboon heart.

With no lasting success and much public uproar, scientists turned from primates to pigs, tinkering with their genes to bridge the species gap.

Pigs have advantages over monkeys and apes. They are produced for food, so using them for organs raises fewer ethical concerns. Pigs have large litters, short gestation periods and organs comparable to those of humans.

Pig heart valves also have been used successfully for decades in humans. The blood thinner heparin is derived from pig intestines. Pig skin grafts are used on burns, and Chinese surgeons have used pig corneas to restore sight.

In the NYU case, researchers kept a deceased woman’s body on a ventilator after her family agreed to the experiment. The woman had wished to donate her organs, but they weren’t suitable for traditional donation.

‘Good could come from this’

The family felt “there was a possibility that some good could come from this gift,” Montgomery said.

Montgomery himself received a transplant three years ago, a human heart from a donor with hepatitis C because he was willing to take any organ.

“I was one of those people lying in an ICU waiting and not knowing whether an organ was going to come in time,” he said.

Several biotech companies are in the running to develop suitable pig organs for transplant to help ease the human organ shortage. More than 90,000 people in the U.S. are in line for kidney transplants. Every day, 12 die while waiting.

The advance is a win for Revivicor, a subsidiary of United Therapeutics, the company that engineered the pig and its cousins, a herd of 100 raised in tightly controlled conditions at a facility in Iowa.

The pigs lack a gene that produces alpha-gal, the sugar that provokes an immediate attack from the human immune system.

In December, the Food and Drug Administration approved the gene alteration in the Revivicor pigs as safe for human food consumption and medicine.

But the FDA said developers would need to submit more paperwork before pig organs could be transplanted into living humans.

“This is an important step forward in realizing the promise of xenotransplantation, which will save thousands of lives each year in the not-too-distant future,” said United Therapeutics CEO Martine Rothblatt in a statement.

Experts say tests on nonhuman primates and last month’s experiment with a human body pave the way for the first experimental pig kidney or heart transplants in living people in the next several years.

Raising pigs to be organ donors feels wrong to some people, but it may grow more acceptable if concerns about animal welfare can be addressed, said Karen Maschke, a research scholar at the Hastings Center, who will help develop ethics and policy recommendations for the first clinical trials under a grant from the National Institutes of Health.

“The other issue is going to be: Should we be doing this just because we can?” Maschke said.
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A French woman of African origin is leading a campaign to encourage more members of France’s African diaspora to register as bone marrow donors to potentially save lives. Elhame Lecoeur filed this report for VOA from Paris, narrated by Michael Lipin.

Camera: Elhame Lecoeur Produced by: Marcus Harton
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A French woman of African origin is leading a campaign to encourage more members of France’s African diaspora to register as bone marrow donors to potentially save lives. Elhame Lecoeur filed this report for VOA from Paris, narrated by Michael Lipin.
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New York City Mayor Bill de Blasio announced a vaccine mandate for city workers Wednesday.

The order calls for employees, including police officers and firefighters, to have received at least one dose of a COVID-19 vaccine by October 29 or else they will be placed on unpaid leave.

The mayor’s office said the mandate applies to about 160,500 workers, and that 71% of them have already received one COVID-19 vaccine dose.

“There is no greater privilege than serving the people of New York City, and that privilege comes with a responsibility to keep yourself and your community safe,” de Blasio said in a statement.
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Authors of a new report on Africa’s climate warn the continent is heating up more and faster than other regions in the world, and they said Africa needs immediate financial and technological assistance to adapt to the warming environment.

The African continent is home to 17% of the global population but is responsible for less than 4% of greenhouse gas emissions, which are leading to climate change.

The report finds changing precipitation patterns, rising temperatures and extreme weather triggered by climate change are happening globally, but notes these events are occurring with greater frequency and intensity in Africa. 

Secretary-General of the World Meteorological Organization, Petteri Taalas said there were 700 major disasters on the continent last year. He said more than half have been flooding events, and one-sixth have been storming and drought events, respectively. 

“We have seen almost 100 million people who have suffered of food insecurity, and they needed humanitarian assistance … and the combined events of conflicts, climate hazards, and especially this COVID-19, they have been contributing to the increase of 40% of food insecurity,” Taalas said

This multi-agency report, entitled State of the Climate in Africa 2020, was coordinated by the World Meteorological Organization, with the help of the African Union Commission and various U.N. agencies.

The report finds the warming trend over the last three decades in all African subregions was stronger than in the previous 30 years. During this period, it said Africa has warmed faster than the global average temperature over land and ocean combined. 

It said higher-than-normal precipitation and flooding predominated in places such as the Sahel, the Rift Valley, and the Kalahari basin. At the same time, dry conditions prevailed in the northern coast of the Gulf of Guinea and other locations, while drought in Madagascar triggered a humanitarian crisis. 

Taalas said sea-level rise is threatening many coastal cities in Africa, like Lagos, Nigeria’s economic hub and a major financial center in Africa. He said climate change also is having a devastating impact on the last remaining glaciers in East Africa. 

“The three African glaciers, Mount Kenya, the Rwenzori, and Kilimanjaro —and you can see that there has been a major loss of the sea ice area and also sea ice mass,” Taalas said. “And if the current trends continue, we will not see any glaciers in Africa in the 2040s.”

The African Union Commission reports adaptation costs in sub-Saharan Africa are estimated at $30 billion to $50 billion, equivalent to two to three percent of regional gross domestic product each year over the next decade. 

However, it notes the cost of doing nothing will be much higher. By 2030, it said up to 118 million extremely poor people will be subject to devastating impacts of drought and intense heat. It adds subsequent displacement and migration consequently will lead to a further 3% decrease in GDP by 2050. 
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