Health officials in the U.S. state of California said a patient there has been infected with a coronavirus variant first detected in Britain, and that it is likely more cases will be identified in the United States.California is the second state with the COVID-19 variant strain, following a case in Colorado earlier this week.As was true with the Colorado case, the California Department of Public Health said the person infected there also had no known travel history.California Health and Human Services Secretary Mark Ghaly called the development “concerning” and stressed the importance of known methods of preventing coronavirus spread, such as wearing masks, social distancing, staying home and avoiding travel.”It appears that this particular mutation does make the virus better at transmitting from one person to another,” said Dr. Anthony Fauci, the top U.S. infectious disease specialist.During an online discussion Wednesday with California Gov. Gavin Newsom, Fauci said virus mutations are normal, and that he was “not surprised” additional cases of the COVID-19 variant would be found in the country.He also said the variant is not believed to cause more severe illness than earlier forms, and that vaccines already being deployed should be just as effective against it.The United States has begun vaccinations of frontline health care workers and high-risk populations such as those living in nursing homes using two vaccines given emergency use authorization.The vaccines will then be made available to other groups in the coming months.Fauci said if the vaccination program progresses as it should through May, June and July, then by early fall there will be “enough good herd immunity to be able to really get back to some strong semblance of normality – schools, theaters, sports events, restaurants.”The United States has recorded 342,000 COVID-19 deaths, including more than 3,700 on Wednesday, according to the Johns Hopkins Coronavirus Resource Center.
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Tough New Year’s Eve restrictions are being put in place as Australia’s biggest city struggles to contain growing coronavirus clusters.Sydney’s COVID-19 outbreak has been described by health officials as “a bit of a roller coaster ride.” Australia’s biggest city accounts for most of the estimated 204 active infections across the country.Parts of its northern coastal suburbs, where a cluster of cases emerged about two weeks ago, remain in lockdown. Infections have been detected in other parts of the city.The authorities have banned large gatherings on New Year’s Eve to “avoid super spreading events.” Sydney’s famous fireworks display will go ahead, but crowds won’t be allowed to gather around the harbor to watch.Gatherings have been limited, and visits to nursing homes banned for at least a week to try to curb the spread of the virus.“Please, the last thing we want is to welcome in 2021 with a super-spreading event,” said New South Wales Premier Gladys Berejiklian. “2021, all of us are hoping, will be easier on us than 2020 and let us start the year off on a positive foot by doing the right thing, by respecting the restrictions that are in place, but also demonstrating common sense.”Experts are calling for the state government to impose a citywide lockdown as infections grow.In response, other Australian states and territories are restricting travel for residents from Sydney.In Victoria, six coronavirus cases have been reported in the past two days, which authorities have linked to infections further north in Sydney.Residents in Victoria are being urged not to travel to neighboring New South Wales, and masks will become mandatory indoors. Residents are not required to wear a mask inside their own homes, but they must if they visit friends or go shopping.Victoria’s Health Minister Martin Foley said a swift response to the outbreak is needed.“Now that we have got links to the New South Wales outbreaks here in Victoria, we are having to respond really quickly to get on top of that, and a part of that is to make sure that as the situation seemingly continues to deteriorate in New South Wales that we respond appropriately,” he said.Australia has recorded 28,380 COVID-19 cases since the pandemic began. Its just over 200 active estimated COVID-19 cases is small by many international standards, but in the context of Australia, a country that has taken a very cautious approach to the virus, the number is cause for alarm.With fewer than 1,000 deaths related to COVID-19 since the pandemic, Australia has fared better than many other developed nations.Health officials in Sydney have blamed “an avalanche of complacency” for recent outbreaks.
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Does it spread more easily? Make people sicker? Mean that treatments and vaccines won’t work? Questions are multiplying as fast as new variants of the coronavirus, especially the one moving through England and now popping up in the U.S. and other countries.Scientists say there is reason for concern and more to learn but that the new variants should not cause alarm.Worry has been growing since before Christmas, when Britain’s prime minister said the coronavirus variant seemed to spread more easily than earlier ones and was moving rapidly through England. On Tuesday, Colorado health officials said they had found it there. And on Wednesday, California officials reported a case.Here are some questions and answers on what’s known about the virus so far.Q: Where did this new variant come from?A: New variants have been seen almost since the virus was first detected in China nearly a year ago. Viruses often mutate, or develop small changes, as they reproduce and move through a population.Most changes are trivial. “It’s the change of one or two letters in the genetic alphabet that doesn’t make much difference in the ability to cause disease,” said Dr. Philip Landrigan, a former Centers for Disease Control and Prevention scientist who directs a global health program at Boston College.A more concerning situation is when a virus mutates by changing the proteins on its surface to help it escape from drugs or the immune system, or if it acquires a lot of changes that make it very different from previous versions.Q: How does one variant become dominant?A: That can happen if one variant takes hold and starts spreading in an area, or because “super spreader” events helped it become established.It also can happen if a mutation gives a new variant an advantage, such as helping it spread more easily than other ones that are circulating.Scientists are still working to confirm whether the variant in England spreads more easily, but they are finding some evidence that it does. The variant “out-competes the other strains and moves faster and infects more people, so it wins the race,” Landrigan said.The British variant was first detected in September, WHO officials said. A new South African variant also has emerged.Q: What’s worrisome about the British variant?A: It has many mutations — nearly two dozen — and eight are on the spike protein that the virus uses to attach to and infect cells. The spike is what vaccines and antibody drugs target.Dr. Ravi Gupta, a virus expert at the University of Cambridge in England, said modeling studies suggest it may be up to two times more infectious than the version that’s been most common in England so far. He and other researchers posted a report of it on a website scientists use to quickly share developments, but it has not been formally reviewed or published in a journal.Q: Does it make people sicker or more likely to die?A: “There’s no indication that either of those is true, but clearly those are two issues we’ve got to watch,” Landrigan said. As more patients get infected with the new variant, “they’ll know fairly soon if the new strain makes people sicker.”A WHO outbreak expert, Maria Van Kerkhove, said that “the information that we have so far is that there isn’t a change” in the kind of illness or its severity.Q: What do the mutations mean for treatments?A: A couple of cases in England raise concern that the mutations in some of the emerging new variants could hurt the potency of drugs that supply antibodies to block the virus from infecting cells.Studies on antibody response are under way, Van Kerkhove said.One drugmaker, Eli Lilly, said that tests in its lab suggest that its drug remains fully active.Q: What about vaccines?A: Scientists believe current vaccines will still be effective against the variant, but they are working to confirm that. On Wednesday, British officials reiterated that there is no data suggesting the new variant hurts the effectiveness of the available vaccines.Vaccines induce broad immune system responses besides just prompting the immune system to make antibodies to the virus, so they are expected to still work, several scientists said.Q: What can I do to reduce my risk?A: Follow the advice to wear a mask, wash your hands often, maintain social distance and avoid crowds, public health experts say.”The bottom line is we need to suppress transmission” of the coronavirus, said the WHO’s director-general, Dr. Tedros Adhanom Ghebreyesus.”The more we allow it to spread, the more mutations will happen.”  
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California on Wednesday announced the nation’s second confirmed case of the new and apparently more contagious variant of the coronavirus, offering a strong indication that the infection is spreading more widely in the United States.Gov. Gavin Newsom announced the infection found in Southern California during an online conversation with Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases.”I don’t think Californians should think that this is odd. It’s to be expected,” Fauci said.Newsom did not provide any details about the person who was infected.The announcement came 24 hours after word of the first reported U.S. variant infection, which emerged in Colorado. That person was identified Wednesday as a Colorado National Guardsman who had been sent to help out at a nursing home struggling with an outbreak. Health officials said a second Guard member may have it, too.The cases triggered a host of questions about how the version circulating in England arrived in the U.S. and whether it is too late to stop it now, with top experts saying it is probably already spreading elsewhere in the United States.”The virus is becoming more fit, and we’re like a deer in the headlights,” warned Dr. Eric Topol, head of Scripps Research Translational Institute. He noted that the U.S. does far less genetic sequencing of virus samples to discover variants than other developed nations, and thus was probably slow to detect this new mutation.The two Guard members had been dispatched Dec. 23 to work at the Good Samaritan Society nursing home in the small town of Simla, in a mostly rural area about 90 miles outside Denver, said Dr. Rachel Herlihy, state epidemiologist. They were among six Guard members sent to the home.Nasal swab samples taken from the two as part of the Guard’s routine coronavirus testing were sent to the state laboratory, which began looking for the variant after its spread was announced in Britain earlier this month, Herlihy said. Samples from staff and residents at the nursing home are also being screened for the variant at the lab, but so far no evidence of it has been found, she said.The Colorado case announced Tuesday involves a man in his 20s who had not traveled recently, officials said. He has mild symptoms and is isolating at his home near Denver, while the person with the suspected case is isolating at a Colorado hotel while further genetic analysis is done on his sample, officials said.The nursing home said it is working closely with the state and is also looking forward to beginning vaccinations next week.Several states, including California, Massachusetts and Delaware, are also analyzing suspicious virus samples for the variant, said Dr. Greg Armstrong, who directs genetic sequencing at the Centers for Disease Control and Prevention. He said the CDC is working with a national lab that gets samples from around the country to broaden that search, with results expected within days.The discovery in Colorado has added urgency to the nation’s vaccination drive against COVID-19, the disease caused by the coronavirus, that has killed more than 340,000 people and sickened nearly 20 million in the U.S., according to Johns Hopkins University.Johns Hopkins said 3,927 people died Wednesday of COVID-19 in the U.S., a new daily record.Britain is seeing infections soar and hospitalizations climb to their highest levels on record. The variant has also been found in several other countries.Scientists have found no evidence that it is more lethal or causes more severe illness, and they believe the vaccines now being dispensed will be effective against it. But a faster-spreading virus could swamp hospitals with seriously ill patients.The discovery overseas led the CDC to issue rules on Christmas Day requiring travelers arriving from Britain to show proof of a negative COVID-19 test. But U.S. health officials said the Colorado patient’s lack of travel history suggests the new variant is already spreading in this country.Topol said it is too late for travel bans.”We’re behind in finding it. Colorado is likely one of many places it’s landed here,” he said. “It’s all over the place. How can you ban travel from everywhere?”Colorado public health officials are conducting contact tracing to determine its spread.Researchers estimate the variant is 50% to 70% more contagious, said Dr. Eric France, Colorado’s chief medical officer.”Instead of only making two or three other people sick, you might actually spread it to four or five people,” France said. “That means we’ll have more cases in our communities. Those number of cases will rise quickly and, of course, with more cases come more hospitalizations.”London and southeast England were placed under strict lockdown measures earlier this month because of the variant, and dozens of countries banned flights from Britain. France also briefly barred trucks from Britain before allowing them back in, provided the drivers got tested for the virus.New versions of the virus have been seen almost since it was first detected in China a year ago. It is common for viruses to undergo minor changes as they reproduce and move through a population. The fear is that mutations at some point will become significant enough to defeat the vaccines.South Africa has also discovered a highly contagious COVID-19 variant that is driving the country’s latest spike of cases, hospitalizations and deaths.  
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College students say clearer communications with their institutions could improve learning during the COVID-19 pandemic that has limited most classes to online.Better communications include transparent decision-making, a 24/7 chatbot, text messaging and better IT support, according to a poll of 2,200 students and staff in Spain, the United States, Britain, Australia, France, the Netherlands and the Nordic countries of Norway, Sweden, Finland and Denmark.While all students reported diminished trust with university leadership during the pandemic, students in the U.S., Britain and Spain reported the greatest amount of disconnect from their institutions.Students and staff also asked for testing for COVID-19 and personal protection equipment (PPE) such as masks. Contact tracing was another measure students and staff said was important.To date, COVID-19 has killed more than 1.8 million people worldwide, including 341,000 in the U.S., according to Johns Hopkins University.When asked, “What are your expectations of your institutions in moving forward?” students said they wanted more career advice, support and “credentials other than a degree,” such as internships or co-ops.Students also asked for more flexibility in their online education, such as course options and scheduling around other responsibilities, like jobs.Reduced tuition and more financial aid were ways institutions could help students during the pandemic, the student respondents said.Despite complaints about online learning, 44% of students polled agreed that they were learning as much online as they would in person, while 32% disagreed and 25% were neutral on the issue.The poll was conducted in August and September 2020 by the research arm of the customer-management company, Salesforce. The questionnaire was devised by Ipsos, Salesforce.org and the Chronicle for Higher Education. The poll was released in November.
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Britain became the first country to approve the coronavirus vaccine developed jointly by Oxford University and AstraZeneca Wednesday. Scientists say the vaccine could be a game changer in the global fight against the pandemic.   Regulators say the vaccine has shown around 70% effectiveness against COVID-19, a relatively high figure compared to vaccines for many other diseases.   “This vaccine, COVID-19 vaccine AstraZeneca, has been approved for use in people aged 18 years and older, with two standard doses, four to 12 weeks apart,” said Dr. June Raine, CEO of Britain’s Medicines and Healthcare products Regulatory Agency (MHRA).   “As I’ve said before, and I will say again today, the safety of the public always comes first. The MHRA’s approval has been reached following a thorough and scientifically rigorous review of all the evidence of safety, of quality and of effectiveness of the COVID-19 vaccine AstraZeneca,” Raine added, during a press conference Wednesday in London.   Earlier in December, Britain was the first of several Western nations to approve the Pfizer-BioNTech vaccine, which is around 95% effective. However, it is more expensive at around $20 per dose and must be stored at minus 70 degrees Celsius.   In contrast, the Oxford-AstraZeneca vaccine costs around $4 per dose and only needs to be stored at refrigerator temperatures.  In an interview with VOA, Dr. Simon Clarke, a microbiologist at the University of Reading in Britain, said those attributes make the drug particularly suitable for less well-funded health systems.  “Developing countries with a less sophisticated cold chain and with smaller budgets will be able to use this vaccine,” Clarke said. Research into the optimum dosing regimen for the AstraZeneca vaccine is ongoing. Britain plans to administer the first dose to as many people as possible, rather than focusing only on elderly and vulnerable groups. A second dose will follow up to 12 weeks later for longer-term protection. Wei Shen Lim, chair of Britain’s Joint Committee on Vaccination and Immunization, explained the decision.  “What is impressive about the vaccine studies is that after the first dose, individuals acquire a high level of protection shortly after the dose. Currently in the U.K., we know that COVID infection rates are very, very high. The immediate urgency is for rapid and high levels of vaccine uptake,” he told the press conference Wednesday.   Clarke said questions remain on the British government’s approach. “There is government pressure to increase the coverage of vaccination. And that’s understandable,” he said. “People want it done as quickly as possible. But if you end up putting more people in [the] hospital because they’re vulnerable and they didn’t get the regimen of the vaccine, then that means that our hospitals are still going to be under pressure.”   Matt Hancock, Britain’s health secretary, said the approval was a cause for great optimism.  “I’m confident … that the NHS will be able to deliver these shots into people’s arms at the speed at which it can be manufactured,” he told Sky News. “And I’m also now, with this approval this morning, highly confident that we can get enough vulnerable people vaccinated by the spring, that we can now see our route out of this pandemic.”   The road to recovery will be difficult. Britain is struggling with a surge of infections driven by a new variant of the coronavirus that doctors say is over 50% more infectious. There are record numbers of hospitalizations, with patients being treated in ambulances as hospital beds are running short.   “Control room staff are having to make incredibly difficult decisions to decide who gets an ambulance and in what order, quite often with huge numbers of people waiting for ambulances,” said Will Broughton, a trustee at Britain’s College of Paramedics. “And they have nobody left to send.”   Several cases of the new mutant virus have been found in other countries. Scientists say its spread makes the global rollout of vaccines even more urgent.       
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